発表論文 Papers

  1. Fukuoka S, Arita R, Mizoguchi T, Kawashima M, Koh S, Shirakawa R, Suzuki T, Sasaki S, Morishige N. Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado-Takushima Study. J Clin Med. 2021 Jan 18;10(2):350. doi: 10.3390/jcm10020350.PMID: 33477594
  2. Arita R, Fukuoka S. Efficacy of Azithromycin Eyedrops for Individuals With Meibomian Gland Dysfunction-Associated Posterior Blepharitis. Eye Contact Lens. 2021 Jan 1;47(1):54-59. doi: 10.1097/ICL.0000000000000729.PMID: 32649390
  3. Arita R, Fukuoka S, Kawashima M. Proposed Algorithm for Management of Meibomian Gland Dysfunction Based on Noninvasive Meibography. J Clin Med. 2020 Dec 27;10(1):65. doi: 10.3390/jcm10010065.PMID: 33375436
  4. Jin K, Kawashima M, Ito M, Arita R, Sano K, Tsubota K.J Clin Med. 2020 Dec 22;10(1):6. doi: 10.3390/jcm10010006.PMID: 33375143
  5. Arita R, Fukuoka S, Mizoguchi T, Morishige N. Multicenter Study of Intense Pulsed Light for Patients with Refractory Aqueous-Deficient Dry Eye Accompanied by Mild Meibomian Gland Dysfunction. J Clin Med. 2020 Oct 28;9(11):3467. doi: 10.3390/jcm9113467.PMID: 33126504
  6. Saito A, Iwashita H, Kitamura Y, Miwa Y, Arita R. Punctate fluorescein staining scores in dogs with or without aqueous tear deficiency. Vet Ophthalmol. 2021 Jan;24(1):28-36. doi: 10.1111/vop.12829. Epub 2020 Sep 22.PMID: 32961030
  7. Inoue S, Kawashima M, Arita R, Kozaki A, Tsubota K. Investigation of Meibomian Gland Function and Dry Eye Disease in Patients with Graves' Ophthalmopathy. J Clin Med. 2020 Aug 31;9(9):2814. doi: 10.3390/jcm9092814.PMID: 32878140
  8. Shimizu S, Arita R, Kawashima M, Inoue S, Itoh K, Tsubota K. Morphological Changes of Meibomian Glands in Men With Benign Prostate Hyperplasia.Cornea. 2020 Aug 19. doi: 10.1097/ICO.0000000000002454. Online ahead of print.PMID: 32826647
  9. Tashbayev B, Yazdani M, Arita R, Fineide F, Utheim TP. Intense pulsed light treatment in meibomian gland dysfunction: A concise review. Ocul Surf. 2020 Oct;18(4):583-594. doi: 10.1016/j.jtos.2020.06.002. Epub 2020 Jul 3.PMID: 32629039 Review.
  10. Fineide F, Arita R, Utheim TP. The role of meibography in ocular surface diagnostics: A review. Ocul Surf. 2021 Jan;19:133-144. doi: 10.1016/j.jtos.2020.05.004. Epub 2020 May 19.PMID: 32416235
  11. Kitamura Y, Arita R, Miwa Y, Iwashita H, Saito A. Histopathologic changes associated with Meibomian Gland dropout in a dog.Vet Ophthalmol. 2020 May;23(3):575-578. doi: 10.1111/vop.12754. Epub 2020 Mar 18.PMID: 32187833
  12. Arita R. Special collection from the Lid and Meibomian Gland Working Group.
    Ocul Surf. 2020 Apr;18(2):191-192. doi: 10.1016/j.jtos.2020.01.002. Epub 2020 Jan 24.PMID: 31987918
  13. Arita R, Fukuoka S. Non-pharmaceutical treatment options for meibomian gland dysfunction.
    Clin Exp Optom. 2020 Nov;103(6):742-755. doi: 10.1111/cxo.13035. Epub 2020 Jan 13.PMID: 31943385 Review.
  14. Fukuoka S, Arita R. Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: a randomized clinical study. Sci Rep. 2019 Jun 24;9(1):9091. doi: 10.1038/s41598-019-45475-7.PMID: 31235821 Clinical Trial.
  15. Arita R, Yabusaki K, Hirono T, Yamauchi T, Ichihashi T, Fukuoka S, Morishige N. Automated Measurement of Tear Meniscus Height with the Kowa DR-1α Tear Interferometer in Both Healthy Subjects and Dry Eye Patients.Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2092-2101. doi: 10.1167/iovs.18-24850.PMID: 31091317
  16. Arita R, Mizoguchi T, Fukuoka S, Morishige N. Reply. Cornea. 2019 May;38(5):e15-e16. doi: 10.1097/ICO.0000000000001903.PMID: 30865047 No abstract available.
  17. Arita R, Mizoguchi T, Kawashima M, Fukuoka S, Koh S, Shirakawa R, Suzuki T, Morishige N. Meibomian Gland Dysfunction and Dry Eye Are Similar but Different Based on a Population-Based Study: The Hirado-Takushima Study in Japan. Am J Ophthalmol. 2019 Nov;207:410-418. doi: 10.1016/j.ajo.2019.02.024. Epub 2019 Mar 7.PMID: 30851269
  18. Villani E, Arita R. Imaging of meibomian glands: from bench to bedside and back. Eye (Lond). 2019 May;33(5):695-697. doi: 10.1038/s41433-019-0351-0. Epub 2019 Feb 6.PMID: 30728489 No abstract available.
  19. Kitamura Y, Maehara S, Nakade T, Miwa Y, Arita R, Iwashita H, Saito A. Assessment of meibomian gland morphology by noncontact infrared meibography in Shih Tzu dogs with or without keratoconjunctivitis sicca. Vet Ophthalmol. 2019 Nov;22(6):744-750. doi: 10.1111/vop.12645. Epub 2019 Feb 4.PMID: 30715776
  20. Arita R, Mizoguchi T, Fukuoka S, Morishige N. Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction. Cornea. 2019 Feb;38(2):e4. doi: 10.1097/ICO.0000000000001779.PMID: 30418276
  21. Ohtomo K, Arita R, Shirakawa R, Usui T, Yamashita H, Seto Y, Yamagami S; TS-1 Multicenter Study Group. Quantitative Analysis of Changes to Meibomian Gland Morphology Due to S-1 Chemotherapy. Transl Vis Sci Technol. 2018 Dec 28;7(6):37. doi: 10.1167/tvst.7.6.37. eCollection 2018 Nov.PMID: 30619657
  22. Arita R, Mizoguchi T, Fukuoka S, Morishige N. Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction. Cornea. 2018 Dec;37(12):1566-1571. doi: 10.1097/ICO.0000000000001687.PMID: 30004962
  23. Arita R, Fukuoka S, Morishige N. Therapeutic efficacy of intense pulsed light in patients with refractory meibomian gland dysfunction. Ocul Surf. 2019 Jan;17(1):104-110. doi: 10.1016/j.jtos.2018.11.004. Epub 2018 Nov 13.PMID: 30445177 Clinical Trial.
  24. Arita R. Meibography: A Japanese Perspective. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES48-DES55. doi: 10.1167/iovs.17-23631.PMID: 30481806 Review.
  25. Arita R, Fukuoka S, Morishige N. Functional Morphology of the Lipid Layer of the Tear Film. Cornea. 2017 Nov;36 Suppl 1:S60-S66. doi: 10.1097/ICO.0000000000001367.PMID: 28957980 Review.
  26. Arita R, Fukuoka S, Morishige N. New Insights Into the Lipid Layer of the Tear Film and Meibomian Glands. Eye Contact Lens. 2017 Nov;43(6):335-339. doi: 10.1097/ICL.0000000000000369.PMID: 28410282 Review.
  27. Mizoguchi S, Iwanishi H, Arita R, Shirai K, Sumioka T, Kokado M, Jester JV, Saika S. Ocular surface inflammation impairs structure and function of meibomian gland. Exp Eye Res. 2017 Oct;163:78-84. doi: 10.1016/j.exer.2017.06.011.PMID: 28950941 Review.
  28. Arita R, Fukuoka S, Morishige N.  New insights into the morphology and function of meibomian glands. Exp Eye Res. 2017 Oct;163:64-71. doi: 10.1016/j.exer.2017.06.010.PMID: 28950939 Review.
  29. Mizoguchi T, Arita R, Fukuoka S, Morishige N.  Morphology and Function of Meibomian Glands and Other Tear Film Parameters in Junior High School Students. Cornea. 2017 Aug;36(8):922-926. doi: 10.1097/ICO.0000000000001252.PMID: 28628504
  30. Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K, Gupta PK, Karpecki P, Lazreg S, Pult H, Sullivan BD, Tomlinson A, Tong L, Villani E, Yoon KC, Jones L, Craig JP.  TFOS DEWS II Diagnostic Methodology report. Ocul Surf. 2017 Jul;15(3):539-574. doi: 10.1016/j.jtos.2017.05.001. Epub 2017 Jul 20.PMID: 28736342 Review.
  31. Arita R, Kawashima M, Ito M, Tsubota K. Clinical safety and efficacy of vitamin D3 analog ointment for treatment of obstructive meibomian gland dysfunction. BMC Ophthalmol. 2017 Jun 7;17(1):84. doi: 10.1186/s12886-017-0482-7.PMID: 28592257 Clinical Trial.
  32. Fukuoka S, Arita R, Shirakawa R, Morishige N. Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion.Clin Ophthalmol. 2017 May 30;11:1031-1038. doi: 10.2147/OPTH.S133060. eCollection 2017.PMID: 28615923
  33. Mizoguchi S, Iwanishi H, Kokado M, Sumioka T, Parfitt GJ, Xie Y, Arita R, Shirakawa R, Yamanaka O, Okada Y, Jester JV, Saika S. Ocular surface alkali injury damages meibomian glands in mice. Ocul Surf. 2017 Oct;15(4):713-722. doi: 10.1016/j.jtos.2017.04.003. Epub 2017 Apr 23.PMID: 28442381
  34. Arita R, Morishige N, Sakamoto I, Imai N, Shimada Y, Igaki M, Suzuki A, Itoh K, Tsubota K. Effects of a warm compress containing menthol on the tear film in healthy subjects and dry eye patients. Sci Rep. 2017 Apr 5;7:45848. doi: 10.1038/srep45848.PMID: 28378793
  35. Fukuoka S, Arita R. Increase in tear film lipid layer thickness after instillation of 3% diquafosol ophthalmic solution in healthy human eyes. Ocul Surf. 2017 Oct;15(4):730-735. doi: 10.1016/j.jtos.2017.03.005. Epub 2017 Mar 28.PMID: 28363586 Clinical Trial.
  36. Arita R, Fukuoka S, Morishige N. Meibomian Gland Dysfunction and Contact Lens Discomfort. Eye Contact Lens. 2017 Jan;43(1):17-22. doi: 10.1097/ICL.0000000000000351.PMID: 28002224 Review.
  37. Suzuki T, Morishige N, Arita R, Koh S, Sakimoto T, Shirakawa R, Miyata K, Ohashi Y. Morphological changes in the meibomian glands of patients with phlyctenular keratitis: a multicenter cross-sectional study. BMC Ophthalmol. 2016 Oct 10;16(1):178. doi: 10.1186/s12886-016-0347-5.PMID: 27724848 Free PMC article.
  38. Tsubota K, Yokoi N, Shimazaki J, Watanabe H, Dogru M, Yamada M, Kinoshita S, Kim HM, Tchah HW, Hyon JY, Yoon KC, Seo KY, Sun X, Chen W, Liang L, Li M, Liu Z; Asia Dry Eye Society.  New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society. Ocul Surf. 2017 Jan;15(1):65-76. doi: 10.1016/j.jtos.2016.09.003. Epub 2016 Oct 8.PMID: 27725302 Review.
  39. Arita R, Morishige N, Fujii T, Fukuoka S, Chung JL, Seo KY, Itoh K. Tear Interferometric Patterns Reflect Clinical Tear Dynamics in Dry Eye Patients.Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3928-34. doi: 10.1167/iovs.16-19788.PMID: 27472080
  40. Arita R, Minoura I, Morishige N, Shirakawa R, Fukuoka S, Asai K, Goto T, Imanaka T, Nakamura M. Development of Definitive and Reliable Grading Scales for Meibomian Gland Dysfunction. Am J Ophthalmol. 2016 Sep;169:125-137. doi: 10.1016/j.ajo.2016.06.025. Epub 2016 Jun 23.PMID: 27345733
  41. Arita R, Mori N, Shirakawa R, Asai K, Imanaka T, Fukano Y, Nakamura M. Linoleic acid content of human meibum is associated with telangiectasia and plugging of gland orifices in meibomian gland dysfunction.Exp Eye Res. 2016 Apr;145:359-362. doi: 10.1016/j.exer.2016.02.005. Epub 2016 Feb 24.PMID: 26919787
  42. Nakayama N, Kawashima M, Kaido M, Arita R, Tsubota K. Analysis of Meibum Before and After Intraductal Meibomian Gland Probing in Eyes With Obstructive Meibomian Gland Dysfunction. Cornea. 2015 Oct;34(10):1206-8 doi:10.1097/ICO.0000000000000558.PMID: 26226474
  43. Arita R, Mori N, Shirakawa R, Asai K, Imanaka T, Fukano Y, Nakamura M, Amano S. Meibum Color and Free Fatty Acid Composition in Patients With Meibomian Gland Dysfunction. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4403-12. doi: 10.1167/iovs.14-16254.PMID: 26176877
  44. Arita R, Morishige N, Shirakawa R, Sato Y, Amano S. Effects of Eyelid Warming Devices on Tear Film Parameters in Normal Subjects and Patients with Meibomian Gland Dysfunction.Ocul Surf. 2015 Oct;13(4):321-30. doi: 10.1016/j.jtos.2015.04.005. Epub 2015 May 30.PMID: 26031204 Clinical Trial.
  45. Arita R, Morishige N, Koh S, Shirakawa R, Kawashima M, Sakimoto T, Suzuki T, Tsubota K. Increased Tear Fluid Production as a Compensatory Response to Meibomian Gland Loss: A Multicenter Cross-sectional Study. Ophthalmology. 2015 May;122(5):925-33. doi: 10.1016/j.ophtha.2014.12.018. Epub 2015 Jan 24.PMID: 25626757
  46. Sano K, Kawashima M, Ikeura K, Arita R, Tsubota K.  Abdominal breathing increases tear secretion in healthy women. Ocul Surf. 2015 Jan;13(1):82-7. doi: 10.1016/j.jtos.2014.08.002. Epub 2014 Oct 16.PMID: 25557347 Clinical Trial.
  47. Nemoto Y, Arita R, Mizota A, Sasajima Y.Clin Ophthalmol. Differentiation between chalazion and sebaceous carcinoma by noninvasive meibography. 2014 Sep 18;8:1869-75. doi: 10.2147/OPTH.S69804. eCollection 2014.PMID: 25258508
  48. Mori N, Fukano Y, Arita R, Shirakawa R, Kawazu K, Nakamura M, Amano S. Rapid identification of fatty acids and (O-acyl)-ω-hydroxy fatty acids in human meibum by liquid chromatography/high-resolution mass spectrometry. J Chromatogr A. 2014 Jun 20;1347:129-36. doi: 10.1016/j.chroma.2014.04.082. Epub 2014 May 1.PMID: 24831422
  49. Arita R. Validity of noninvasive meibography systems: noncontact meibography equipped with a slit-lamp and a mobile pen-shaped meibograph. Cornea. 2013 Nov;32 Suppl 1:S65-70. doi: 10.1097/ICO.0b013e3182a2c7c6.PMID: 24104937 Review.
  50. Efron N, Jones L, Bron AJ, Knop E, Arita R, Barabino S, McDermott AM, Villani E, Willcox MD, Markoulli M; members of the TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on Contact Lens Discomfort: report of the contact lens interactions with the ocular surface and adnexa subcommittee. Invest Ophthalmol Vis Sci. 2013 Oct 18;54(11):TFOS98-TFOS122. doi: 10.1167/iovs.13-13187.PMID: 24058133
  51. Arita R, Suehiro J, Haraguchi T, Shirakawa R, Tokoro H, Amano S. Objective image analysis of the meibomian gland area. Br J Ophthalmol. 2014 Jun;98(6):746-55. doi: 10.1136/bjophthalmol-2012-303014. Epub 2013 Jun 27.PMID: 23813417
  52. Arita R, Shirakawa R, Maeda S, Yamaguchi M, Ohashi Y, Amano S. Decreased surface temperature of tarsal conjunctiva in patients with meibomian gland dysfunction. JAMA Ophthalmol. 2013 Jun;131(6):818-9. doi:10.1001/jamaophthalmol.2013.1895.PMID: 23579390
  53. Arita R, Suehiro J, Haraguchi T, Maeda S, Maeda K, Tokoro H, Amano S. Topical diquafosol for patients with obstructive meibomian gland dysfunction. Br J Ophthalmol. 2013 Jun;97(6):725-9. doi: 10.1136/bjophthalmol-2012-302668. Epub 2013 Apr 12.PMID: 23584719 Clinical Trial.
  54. Shirakawa R, Arita R, Amano S. Meibomian gland morphology in Japanese infants, children, and adults observed using a mobile pen-shaped infrared meibography device.
    Am J Ophthalmol. 2013 Jun;155(6):1099-1103.e1. doi: 10.1016/j.ajo.2013.01.017. Epub 2013 Mar 14.PMID: 23497846
  55. Arita R, Itoh K, Maeda S, Maeda K, Amano S. A newly developed noninvasive and mobile pen-shaped meibography system. Cornea. 2013 Mar;32(3):242-7. doi: 10.1097/ICO.0b013e31825425ef.PMID: 22580439
  56. . Arita R, Itoh K, Maeda S, Maeda K, Furuta A, Tomidokoro A, Aihara M, Amano S. Comparison of the long-term effects of various topical antiglaucoma medications on meibomian glands. Cornea. 2012 Nov;31(11):1229-34. doi: 10.1097/ICO.0b013e31823f8e7d.PMID: 22406943
  57. Arita R, Itoh K, Maeda S, Maeda K, Furuta A, Tomidokoro A, Aihara M, Amano S. Effects of long-term topical anti-glaucoma medications on meibomian glands.Graefes Arch Clin Exp Ophthalmol. 2012 Aug;250(8):1181-5. doi: 10.1007/s00417-012-1943-6. Epub 2012 Feb 18.PMID: 22349978
  58. Arita R, Yanagi Y, Honda N, Maeda S, Maeda K, Kuchiba A, Yamaguchi T, Yanagihara Y, Suzuki H, Amano S. Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.Ophthalmology. 2012 May;119(5):972-8. doi: 10.1016/j.ophtha.2011.11.033. Epub 2012 Feb 14.PMID: 22336631 Clinical Trial.
  59. Arita R, Itoh K, Maeda S, Maeda K, Tomidokoro A, Amano S. Association of contact lens-related allergic conjunctivitis with changes in the morphology of meibomian glands.
    Jpn J Ophthalmol. 2012 Jan;56(1):14-9. doi: 10.1007/s10384-011-0103-6. Epub 2011 Nov 23.PMID: 22109632
  60. Tomlinson A, Bron AJ, Korb DR, Amano S, Paugh JR, Pearce EI, Yee R, Yokoi N, Arita R, Dogru M. The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee. Invest Ophthalmol Vis Sci. 2011 Mar 30;52(4):2006-49. doi: 10.1167/iovs.10-6997f. Print 2011 Mar.PMID: 21450918 Review.
  61. Arita R, Itoh K, Maeda S, Maeda K, Tomidokoro A, Amano S. Efficacy of diagnostic criteria for the differential diagnosis between obstructive meibomian gland dysfunction and aqueous deficiency dry eye. Jpn J Ophthalmol. 2010 Sep;54(5):387-91. doi: 10.1007/s10384-010-0858-1. Epub 2010 Nov 5.PMID: 21052898
  62. Arita R, Itoh K, Maeda S, Maeda K, Furuta A, Tomidokoro A, Amano S. Proposed diagnostic criteria for seborrheic meibomian gland dysfunction. Cornea. 2010 Sep;29(9):980-4. doi: 10.1097/ICO.0b013e3181cc7b1b.PMID: 20628302
  63. Arita R, Itoh K, Maeda S, Maeda K, Furuta A, Tomidokoro A, Amano S. Meibomian gland duct distortion in patients with perennial allergic conjunctivitis.Cornea. 2010 Aug;29(8):858-60. doi: 10.1097/ICO.0b013e3181ca3668.PMID: 20508507
  64. Arita R, Itoh K, Maeda S, Maeda K, Furuta A, Fukuoka S, Tomidokoro A, Amano S. Proposed diagnostic criteria for obstructive meibomian gland dysfunction. Ophthalmology. 2009 Nov;116(11):2058-63.e1. doi: 10.1016/j.ophtha.2009.04.037. Epub 2009 Sep 10.PMID: 19744718
  65. Arita R, Itoh K, Inoue K, Kuchiba A, Yamaguchi T, Amano S. Contact lens wear is associated with decrease of meibomian glands.Ophthalmology. 2009 Mar;116(3):379-84. doi: 10.1016/j.ophtha.2008.10.012. Epub 2009 Jan 22.PMID: 19167077
  66. Mimura T, Amano S, Fukuoka S, Honda N, Arita R, Ochiai M, Yanagisawa M, Usui T, Ono K, Araki F, Yamagami S, Araie M, Awaya Y. In vivo confocal microscopy of hereditary sensory and autonomic neuropathy. Curr Eye Res. 2008 Nov;33(11):940-5. doi: 10.1080/02713680802450992.PMID: 19085376
  67. Arita R, Itoh K, Inoue K, Amano S. Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology. 2008 May;115(5):911-5. doi: 10.1016/j.ophtha.2007.06.031.PMID: 18452765
  68. Arita R, Arita M, Kawai M, Mashima Y, Yamada M. Evaluation of corneal endothelial pump function with a cold stress test. Cornea. 2005 Jul;24(5):571-5. doi: 10.1097/01.ico.0000153559.05150.c2.PMID: 15968163
  69. Itoh R, Kawamoto S, Miyamoto Y, Kinoshita S, Okubo K.Isolation and characterization of a Ca(2+)-activated chloride channel from human corneal epithelium. Curr Eye Res. 2000 Dec;21(6):918-25.
  70. Itoh R, Kawamoto S, Adachi W, Kinoshita S, Okubo K. Genomic organization and chromosomal localization of the human cathepsin L2 gene. DNA Res. 1999 Apr 30;6(2):137-40.
  71. Itoh R , Yokoi N, Kinoshita S. Tear film instability induced by rigid contact lenses. Cornea 1999 Jul;18(4):440-3.
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